Journal article
Genomic Epidemiology Links Burkholderia pseudomallei from Individual Human Cases to B. pseudomallei from Targeted Environmental Sampling in Northern Australia
JR Webb, M Mayo, A Rachlin, C Woerle, E Meumann, V Rigas, G Harrington, M Kaestli, BJ Currie
Journal of Clinical Microbiology | AMER SOC MICROBIOLOGY | Published : 2022
DOI: 10.1128/jcm.01648-21
Abstract
Each case of melioidosis results from a single event when a human is infected by the environmental bacterium Burkholderia pseudomallei. Darwin, in tropical northern Australia, has the highest incidences of melioidosis globally, and the Darwin Prospective Melioidosis Study (DPMS) commenced in 1989, documenting all culture-confirmed melioidosis cases. From 2000 to 2019, we sampled DPMS patients’ environments for B. pseudomallei when a specific location was considered to be where infection occurred, with the aim of using genomic epidemiology to understand B. pseudomallei transmission and infecting scenarios. Environmental sampling was performed at 98 DPMS patient sites, where we collected 975 e..
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Awarded by Menzies School of Health Research
Funding Acknowledgements
We thank our microbiology laboratory colleagues at Royal Darwin Hospital for their support and expertise in B. pseudomallei identification from the clinical cases. We also thank Ian Harrington, Kelly McCrory, Erin Gargan, and Emma Forsyth from Menzies School of Health Research for assistance with laboratory work and environmental sampling. The research was funded under Australian National Health and Medical Research Council grants 1046812, 1098337, and 1131932 (The HOT NORTH initiative).